Publications by authors named "Julien Duysens"
Revealing the Therapeutic Potential of Muscle-Derived Mesenchymal Stem/Stromal Cells: An In Vitro Model for Equine Laminitis Based on Activated Neutrophils, Anoxia-Reoxygenation, and Myeloperoxidase.
Didier Serteyn Nazaré Storms Ange Mouithys-Mickalad Charlotte Sandersen Ariane Niesten Julien Duysens
Animals (Basel)
September 2024
Article Synopsis
- - Laminitis in horses causes severe pain and can lead to euthanasia, prompting research for better treatments through an in vitro model that tests cell responses to stressful conditions.
- - The study found that during reoxygenation, keratinocytes (skin cells) show reduced metabolism, indicating cellular stress, but introducing muscle-derived stem cells helped restore their function.
- - Additionally, exposure to activated neutrophils increased cell activity related to inflammation, which stem cells could help regulate, suggesting their potential use in treating laminitis through cell therapy.
The main causes of mortality in horses are the gastrointestinal pathologies associated with septic shock. Stem cells have shown, through systemic injection, a capacity to decrease inflammation and to regenerate injured tissue faster. Nevertheless, to achieve this rapid and total regeneration, systemic injections of 1 to 2 million cells per kilogram of body weight must be considered.
View Article and Find Full Text PDFWe investigated the antioxidant potential of equine mesenchymal stem cells derived from muscle microbiopsies (mdMSCs), loaded by a water-soluble curcumin lysinate incorporated into hydroxypropyl-β-cyclodextrin (NDS27). The cell loading was rapid and dependent on NDS27 dosage (14, 7, 3.5 and 1 µM).
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