Publications by authors named "Julien Bosson"
A series of ferrocenyl-containing γ-hydroxy-γ-lactam tetramates were prepared in 2-3 steps through ring opening-ring closure (RORC) process of γ-ylidene-tetronate derivatives in the presence of ferrocenyl alkylamines. The compounds were screened in vitro for their antiplasmodial activity against chloroquine-sensitive (3D7) and chloroquine-resistant (W2) clones of P. falciparum, displaying activity in the range of 0.
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- The study reports a simple 2-3 step synthesis of γ-hydroxy-γ-lactam tetramates featuring a 7-chloro-4-aminoquinoline structure and evaluates their effectiveness as potential antimalarial agents.
- The antimalarial activity of these new compounds was tested against different strains of Plasmodium falciparum, showing effectiveness in the range of 14-827nM and generally good resistance indices.
- Additionally, the most promising compounds were found non-toxic to human endothelial cells at concentrations up to 50μM and demonstrated stability in neutral pH conditions for at least 48 hours.
We report on the use of an alkoxyamine (AA) for fabrication of functional micropatterns with complex structures by UV mask lithography. The living character of the polymer surface and the vertical spatial control of the repolymerization reaction from few tens of nanometers to few micrometers were demonstrated. The impact of the main parameters governing the controlled polymerization and the reinitiation process activated by light or heat was investigated.
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