Taming the Lewis Superacid Al(ORF) (RF=C(CF ) ): DFT Guided Identification of the "Stable yet Reactive" Adduct SiPr →Al(ORF) ; Its Use as ORF- Abstractor from a "Ni-ORF" complex.

A DFT study of several L→Al(OR ) (L=Lewis bases) adducts allowed the identification of ( Pr S)→Al(OR ) 1-S Pr as a "stable yet reactive" adduct. 1-S Pr was shown to act as a masked Lewis superacid able to release Al(OR ) under mild conditions. It could be used to abstract a OR ligand from (bipyMe )Ni(OR ) (bipyMe  : 6,6'-dimethyl-2,2'-dipyridyl) and generate the nickel alkoxide complex [(bipyMe )Ni(OR )( Pr S)] [(R O) Al-F-Al(OR ) ] 5.

Ligand-enabled oxidation of gold(i) complexes with -quinones.

Chelating P^P and hemilabile P^N ligands were found to trigger the oxidation of Au(i) complexes by -benzoquinones. The ensuing Au(iii) catecholate complexes have been characterized by NMR spectroscopy, single crystal X-ray diffraction and X-ray absorption spectroscopy. They adopt tetracoordinate square-planar structures.

Design of cytocompatible bacteria-repellent bio-based polyester films via an aqueous photoactivated process.

Nosocomial infections are often induced by the presence of pathogenic organisms on the surface of medical devices or hospital equipment. Chemical or topographical modifications of the surface are recognized as efficient strategies to prevent bacteria adhesion but they may have negative impact on the material interaction with living tissues. Here we have developed a photoactivated method for the modification of a biocompatible polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) under aqueous conditions.

Photoinduced modification of the natural biopolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microfibrous surface with anthraquinone-derived dextran for biological applications.

A straightforward and versatile method for immobilizing polysaccharides on the surface of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) electrospun fibers is developed with the objective of designing a new functional biomaterial having a significant effect on cell proliferation. The approach relies on a one-step procedure: UV grafting of a photosensitive dextran (AQ-Dext) on the surface of PHBHV fibers according to a "grafting onto" method, with the use of an anthraquinone derivative. The photografting is conducted through a photoinduced free radical process employing an anthraquinone-based photosensitizer in aqueous medium.

Facile synthesis of multicompartment micelles based on biocompatible poly(3-hydroxyalkanoate).

In this paper, a straightforward method to produce poly(3-hydroxyalkanoate)-based multicompartment micelles (MCMs) is presented. Thiol-ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3-hydroxyoctanoate-co-hydroxyundecenoate) oligomers backbone. Well-defined copolymers are obtained as shown by ¹H NMR and size-exclusion chromatography.

An efficient thiol-ene chemistry for the preparation of amphiphilic PHA-based graft copolymers.

We present a straightforward method to prepare amphiphilic graft copolymers consisting of hydrophobic poly(3-hydroxyalkanoates) (PHAs) backbone and hydrophilic α-amino-ω-methoxy poly(oxyethylene-co-oxypropylene) (Jeffamine®) units. Poly(3-hydroxyoctanoate)-co-(3-hydroxyundecenoate) (PHOU) was first methanolyzed to obtain the desired molar mass. The amino end groups of Jeffamine were converted into thiol by a reaction with N-acetylhomocysteine thiolactone and subsequently photografted.

Poly(3-hydroxyalkanoate)-derived amphiphilic graft copolymers for the design of polymersomes.

Amphiphilic graft copolymers composed of biocompatible bacterial poly(3-hydroxyalkanoate) and poly(ethylene glycol) have been synthesized by thiol-ene addition. They were demonstrated to form well-defined nanoscale vesicles in water by cryo-transmission electron microscopy.

A micellization study of medium chain length poly(3-hydroxyalkanoate)-based amphiphilic diblock copolymers.

In this article, we report the first micellization study of amphiphilic copolymers composed of bacterial medium chain length poly(3-hydroxyalkanoates) (mcl-PHAs). A series of diblock copolymers based on fixed poly(ethylene glycol) (PEG) block (5000 g mol(-1)) and a varying poly(3-hydroxyoctanoate-co-3-hydroxyhexanoate) (PHOHHx) segment (1500-7700 g mol(-1)) have been synthesized using "click" chemistry. These copolymers self-assembled to form micelles in aqueous media.

Preparation of Clickable Poly(3-hydroxyalkanoate) (PHA): Application to Poly(ethylene glycol) (PEG) Graft Copolymers Synthesis.

A new synthesis of amphiphilic biodegradable copolymers consisting of hydrophobic poly(3-hydroxyalkanoate) (PHA) backbone and hydrophilic poly(ethylene glycol) (PEG) units as side chains is described. Poly[(3-hydroxyoctanoate)-co-(3-hydroxyundecenoate)] (PHOU) was first methanolyzed and its unsaturated side chains were quantitatively oxidized to carboxylic acid. Esterification with propargyl alcohol led to an alkyne-containing "clickable" PHA in 71% conversion.