Anatomical Total Shoulder Arthroplasty with Keeled glenoids in Patients under 60 years at 10 years minimum: which risk factors of failure are still valid at long term follow-up?

Aim: To assess the long-term (>10 years) outcomes in anatomical total shoulder arthroplasty (aTSA) and implant survival in patient under 60 years and identify risk factors for complications and revision.

Methods: This was a retrospective, multicenter study conducted from 1993 to 2008. Over 104 aTSA, 87 in 82 patients (55 years, 36 to 60yo) were included at a mean follow-up of 14±4 years (10 to 25y).

Response and resilience of carbon nanotube micropillars to shear flow.

Interactions between carbon nanotubes (CNTs) and fluid flows are central to the operation of several emerging nanotechnologies. In this paper, we explore the fluid-structure interaction of CNT micropillars in wall-bounded shear flows, relevant to recently developed microscale wall shear stress sensors. We monitor the deformation of CNT micropillars in channel flow as the flow rate and wall shear stress are gradually varied.

Objectively assessed school-based intervention to reduce children's sedentary time: a systematic review.

Childhood is a period characterized by a constant increase in sedentary time (ST) but also provides a great window of opportunity for children to learn how to limit ST. As a result, school-based interventions aimed at reducing and preventing children's ST are increasingly becoming more widespread. A previous review found that school-based multi-component interventions appeared to be more effective in comparison to those based on a single component.

Whole-Genome Sequence of Phage Mx9.

Here, we characterize the genome of phage Mx9, a lysogenic, short-tailed phage (genus ) phage infecting the bacterial host Myxococcus xanthus, a model for bacterial evolution and development. The 53.5-kb genome has a GC content of 67.

Mapping the core concepts of physiology across Australian university curricula.

Core concepts in physiology, designed by physiology educators to promote improved learning and teaching, have existed for over a decade. This study aimed to investigate the extent to which a set of 15 core concepts of physiology (developed by Michael and McFarland, U.S.

Influence of process parameters on energetic properties of sputter-deposited Al/CuO reactive multilayers.

In this study, we demonstrate the effect of change of the sputtering power and the deposition pressure on the ignition and the combustion properties of Al/CuO reactive thin films. A reduced sputtering power of Al along with the deposition carried out at a higher-pressure result in a high-quality thin film showing a 200% improvement in the burn rate and a 50% drop in the ignition energy. This highlights the direct implication of the change of the process parameters on the responsivity and the reactivity of the reactive film while maintaining the Al and CuO thin-film integrity both crystallographically and chemically.

Management of appendicitis in a De Garengeot hernia: Lockwood approach.

A De Garengeot hernia is a femoral hernia containing the vermiform appendix. This extremely rare hernia is associated with appendicitis and the risk of perforation and abscess formation. Given limited data, it poses both diagnostic and management difficulties.

A blended learning exercise physiology theory module that supports student autonomy and improves academic performance.

A limited number of studies have explored the impact of blended exercise physiology theory curricula on student learning and experience. This study aimed to investigate the impact of an exercise physiology blended learning theory module on student performance, engagement, and perceptions. The module, which comprised a range of elements (student guide, lecturer-recorded videos, supplementary videos, formative quizzes, workshops, and discussion forum), was implemented in a third-year subject taken by students in nonspecialist undergraduate science, technology, engineering, and mathematics (STEM) degrees.

Impact of Estrogen Withdrawal and Replacement in Female Mice along the Intestinal Tract. Comparison of E2 Replacement with the Effect of a Mixture of Low Dose Pollutants.

Postmenopausal women represent a vulnerable population towards endocrine disruptors due to hormonal deficit. We previously demonstrated that chronic exposure of ovariectomized C57Bl6/J mice fed a high-fat, high-sucrose diet to a low-dose mixture of chemicals with one dioxin, one polychlorobiphenyl, one phthalate, and bisphenol A triggered metabolic alterations in the liver but the intestine was not explored. Yet, the gastrointestinal tract is the main route by which pollutants enter the body.

Teaching students to explain the pathophysiology of diseases to lay audiences with a scaffold that supports student choice.

Expert educators in science argue that science graduates are often lacking skills in effectively communicating scientific information to lay audiences. To address this, we designed a project, Communicating Disease, for final-year undergraduate human pathophysiology students. Students chose a disease, a relevant nonscientific target audience, and a mode of communication and produced a communiqué designed to educate the audience on the pathophysiology of the disease.

Elucidating the dominant mechanisms in burn rate increase of thermite nanolaminates incorporating nanoparticle inclusions.

It was experimentally found that silica and gold particles can modify the combustion properties of nanothermites but the exact role of the thermal properties of these additives on the propagating combustion front relative to other potential contributions remains unknown. Gold and silica particles of different sizes and volume loadings were added into aluminum/copper oxide thermites. Their effects on the flame front dynamics were investigated experimentally using microscopic dynamic imaging techniques and theoretically via a reaction model coupling mass and heat diffusion processes.

How Thermal Aging Affects Ignition and Combustion Properties of Reactive Al/CuO Nanolaminates: A Joint Theoretical/Experimental Study.

The paper reports a joint experimental/theoretical study on the aging of reactive Al/CuO nanolaminates, investigating both structural modifications and combustion properties of aged systems. We first show theoretically that the long-term storage (over several decades) in ambient temperature marginally affects nanolaminates structural properties with an increase in an interfacial layer of only 0.3 nm after 30 years.

Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet: impact of a chronic exposure to a low-dose pollutant mixture.

Postmenopausal women may be at particular risk when exposed to chemicals especially endocrine disruptors because of hormonal deficit. To get more insight, ovariectomized C57Bl6/J mice fed a high-fat high-sucrose diet were chronically exposed from 5 to 20 weeks of age to a low-dose mixture of chemicals with one dioxin, one polychlorobiphenyl, one phthalate and bisphenol A. Part of the mice received as well E2 implants to explore the potential estrogenic dependency of the metabolic alterations.

Usability and acceptability of four systematic review automation software packages: a mixed method design.

Aim: New software packages help to improve the efficiency of conducting a systematic review through automation of key steps in the systematic review. The aim of this study was to gather qualitative data on the usability and acceptability of four systematic review automation software packages (Covidence, SRA-Helper for EndNote, Rayyan and RobotAnalyst) for the citation screening step of a systematic review.

Methods: We recruited three volunteer systematic reviewers and asked them to use allocated software packages during citation screening.

Probiotics for preventing acute otitis media in children.

Background: Acute otitis media (AOM), or acute middle ear infection, is one of the most frequently occurring childhood diseases, and the most common reason given for prescribing antibiotics in this age group. Guidelines often recommend antibiotics as first-line treatment for severe AOM. However, antibiotics also lead to antibiotic resistance, so preventing episodes of AOM is an urgent priority.

Management of stroke in the Australian Indigenous population: from hospitals to communities.

Background: Ischaemic strokes lead to significant morbidity and mortality within the Australian Indigenous population, with known variances in the management of strokes between indigenous and non-indigenous populations.

Aims: To compare investigations and management of indigenous and non-indigenous patients presenting to a New South Wales rural referral hospital with an ischaemic stroke to the national stroke standards across inpatient and outpatient settings.

Methods: Historical cohort study of 43 indigenous and 167 non-indigenous patients admitted to Tamworth Rural Referral Hospital with an ischaemic cerebrovascular accident.

Chronic exposure to a pollutant mixture at low doses led to tissue-specific metabolic alterations in male mice fed standard and high-fat high-sucrose diet.

Excessive consumption of industrialized food and beverages is a major etiologic factor in the epidemics of obesity and associated metabolic diseases because these products are rich in fat and sugar. In addition, they contain food contact materials and environmental pollutants identified as metabolism disrupting chemicals. To evaluate the metabolic impact of these dietary threats (individually or combined), we used a male mouse model of chronic exposure to a mixture of low-dose archetypal food-contaminating chemicals that was added in standard or high-fat, high-sucrose (HFHS) diet.

Metabolomics in chronic kidney disease: Strategies for extended metabolome coverage.

Chronic kidney disease (CKD) is becoming a major public health issue as prevalence is increasing worldwide. It also represents a major challenge for the identification of new early biomarkers, understanding of biochemical mechanisms, patient monitoring and prognosis. Each metabolite contained in a biofluid or tissue may play a role as a signal or as a driver in the development or progression of the pathology.

The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis.

Background & Aims: Liver fibrosis is characterized by the accumulation of extracellular matrix produced by hepatic myofibroblasts (hMF), the activation of which is critical to the fibrogenic process. Extracellular ATP, released by dying or stressed cells, and its purinergic receptors, constitute a powerful signaling network after injury. Although the purinergic receptor P2X4 (P2RX4) is highly expressed in the liver, its functions in hMF had never been investigated during liver fibrogenesis.