Publications by authors named "Julie Wallin"
Experience regulates synapse formation and function across sensory circuits. How inhibitory synapses in the mammalian retina are sculpted by visual cues remains unclear. By use of a sensory deprivation paradigm, we find that visual cues regulate maturation of two GABA synapse types (GABA and GABA receptor synapses), localized across the axon terminals of rod bipolar cells (RBCs)-second-order retinal neurons integral to the night-vision circuit.
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- Early expression of GABA receptors, particularly the α3 subunit, is crucial for developing functional inhibitory circuits in retinal bipolar cells.
- As the cells mature, GABAα3 receptors are replaced by GABAα1 receptors before eye opening, highlighting a key transitional phase in synapse development.
- A deficiency in early GABAα3 disrupts both the clustering of GABAα1 receptors and the organization of essential proteins, ultimately affecting how visual signals are processed by these circuits.
LRRTM4 is a transsynaptic adhesion protein regulating glutamatergic synapse assembly on dendrites of central neurons. In the mouse retina, we find that LRRTM4 is enriched at GABAergic synapses on axon terminals of rod bipolar cells (RBCs). Knockout of LRRTM4 reduces RBC axonal GABA and GABA receptor clustering and disrupts presynaptic inhibition onto RBC terminals.
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