Retrospective Cohort Study on the Impact of the COVID-19 Pandemic on Pregnancy Outcomes for Women Living With HIV in British Columbia.

Background: For pregnant women living with HIV (WLWH), engagement in care is crucial to maternal health and reducing the risk of perinatal transmission. To date, there have been no studies in Canada examining the impact of the COVID-19 pandemic on pregnant WLWH.

Methods: This was a retrospective cohort study assessing the impact of the pandemic on perinatal outcomes for pregnant WLWH using data from the Perinatal HIV Surveillance Program in British Columbia, Canada.

Penicillin de-labelling in vancouver, British Columbia, Canada: comparison of approaches, outcomes and future directions.

Background: Inaccurate penicillin allergy labels lead to inappropriate antibiotic prescriptions and harmful patient consequences. System-wide efforts are needed to remove incorrect penicillin allergy labels, but more health services research is required on how to best deliver these services.

Methods: Data was extracted from five hospitals in Vancouver, British Columbia, Canada from October 2018-May 2022.

Maternal vaginal microbiome composition does not affect development of the infant gut microbiome in early life.

Birth mode has been implicated as a major factor influencing neonatal gut microbiome development, and it has been assumed that lack of exposure to the maternal vaginal microbiome is responsible for gut dysbiosis among caesarean-delivered infants. Consequently, practices to correct dysbiotic gut microbiomes, such as vaginal seeding, have arisen while the effect of the maternal vaginal microbiome on that of the infant gut remains unknown. We conducted a longitudinal, prospective cohort study of 621 Canadian pregnant women and their newborn infants and collected pre-delivery maternal vaginal swabs and infant stool samples at 10-days and 3-months of life.

A practical clinical guide to counselling on and managing contraception, pre-conception planning, and menopause for women living with HIV.

Background: Women represent one quarter of the population living with HIV in Canada and are an increasingly important sector of the HIV community. While some women's health issues such as cervical cancer screening and management are well addressed in HIV management guidelines, others are not. These include sexual and reproductive health factors such as contraception, pre-conception planning, and menopause.

Association of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes.

Importance: There are limited high-quality, population-level data about the effect of SARS-CoV-2 infection on pregnancy using contemporaneous comparator cohorts.

Objectives: To describe maternal and perinatal outcomes associated with SARS-CoV-2 infection in pregnancy and to assess variables associated with severe disease in the pregnant population.

Design, Setting, And Participants: CANCOVID-Preg is an observational surveillance program for SARS-CoV-2-affected pregnancies in Canada.

Menopausal hormone therapy for women living with HIV.

People living with HIV are ageing, and a growing number of women living with HIV are entering menopause. Women living with HIV commonly have bothersome vasomotor symptoms and onset of menopause at earlier ages; both factors go on to affect quality of life and systemic health. Vasomotor symptoms and early menopause are both indications for menopausal hormone therapy; however, current evidence suggests that this therapy is seldom offered to women living with HIV.

Prioritizing Maternal Sepsis: National Adoption of an Obstetric Early Warning System to Prevent Morbidity and Mortality.

Sepsis is one of the leading causes of maternal morbidity and mortality. Analyses have determined that delays in early recognition and prompt initiation of appropriate management are key contributing factors in maternal sepsis deaths. Recent cases of sepsis-related maternal morbidity and mortality across Canada have highlighted the urgent need for a national standardized approach to the detection and treatment of maternal sepsis.

Cervical Cancer Screening in Immunocompromised Women.

In the context of changing recommendations for cervical cancer screening, differing recommendations in each province, and a lack of guidance for cervical screening of immunocompromised women, this article provides specific recommendations for cervical cancer screening of immunocompromised women in Canada.

The association between antiretroviral therapy and early placental function: a cohort study.

To evaluate the association of antiretroviral therapy (ART) type and duration of exposure with early placental function using biomarkers of aneuploidy screening. Three hundred thirty-eight pregnant women living with HIV were enrolled in two Canadian centers. Multiple linear regressions were performed adjusting for confounding factors (race, age, gestational age, body mass index, parity, smoking, and fetal sex).

N 378 - Placentophagie.

La consommation du placenta humain a récemment été mise en évidence. Toutefois, aucune donnée probante ne fait état des bienfaits qui seraient liés à cette pratique. De plus, elle peut nuire à la santé.

No. 378-Placentophagy.

Consumption of human placenta has recently been highlighted; however, there is no evidence of benefit from its consumption. In addition, there is potential for harm. Therefore the SOGC does not recommend the practice of placentophagy.

N 275 - Antibioprophylaxie dans le cadre d'interventions gynécologiques.

Objectif: Analyser les données et formuler des recommandations sur l'antibioprophylaxie dans le cadre d'interventions gynécologiques.

Issues: Parmi les issues évaluées, on trouvait la nécessité du recours aux antibiotiques et leur efficacité pour ce qui est de la prévention des infections dans le cadre d'interventions gynécologiques. RéSULTATS: Des recherches ont été menées dans Medline et The Cochrane Library afin d'en tirer les articles publiés entre janvier 1978 et janvier 2011 sur le sujet de l'antibioprophylaxie dans le cadre d'interventions gynécologiques.

No. 275-Antibiotic Prophylaxis in Gynaecologic Procedures.

Objective: To review the evidence and provide recommendations on antibiotic prophylaxis for gynaecologic procedures.

Outcomes: Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in gynaecologic procedures.

Evidence: Medline and The Cochrane Library were searched for articles published between January 1978 and January 2011 on the topic of antibiotic prophylaxis in gynaecologic procedures.

No. 247-Antibiotic Prophylaxis in Obstetric Procedures.

Objective: To review the evidence and provide recommendations on antibiotic prophylaxis for obstetrical procedures.

Outcomes: Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in obstetrical procedures.

Evidence: Published literature was retrieved through searches of Medline and The Cochrane Library on the topic of antibiotic prophylaxis in obstetrical procedures.

No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes.

Objective: To review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (PPROM).

Outcomes: Outcomes evaluated include the effect of antibiotic treatment on maternal infection, chorioamnionitis, and neonatal morbidity and mortality.

Evidence: Published literature was retrieved through searches of Medline, EMBASE, CINAHL, and The Cochrane Library, using appropriate controlled vocabulary and key words (PPROM, infection, and antibiotics).