Publications by authors named "Julie Toner"
Background: The Australian National Bowel Cancer Screening Program sends an immunochemical faecal occult blood test to Australians aged 50-74 years to screen for bowel cancer, but uptake is low (40.9%). The SMARTscreen trial demonstrated that sending a short messaging services (SMS) prompt from the participant's general practitioner (GP) increased the proportion of kit returns by 16.
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- The study examined the connection between certain bacteria (pks E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum) and colorectal cancer (CRC) by analyzing DNA samples from various cohorts.
- Results revealed that pks E. coli is linked to male CRC patients and a specific APC gene mutation, mainly in early-onset cases, while F. nucleatum correlates with various cancer traits including DNA repair deficiencies and specific tumor locations.
- The findings suggest that pks E. coli might cause DNA damage related to the identified mutation, and F. nucleatum exists in both hereditary and sporadic factors of DNA mismatch repair deficiencies, highlighting the importance of the tumor environment for bacterial colon
Background: Australia has one of the highest incidences of colorectal cancer (CRC) worldwide. The Australian National Bowel Cancer Screening Program (NBCSP) is a best-practice, organised screening programme, but uptake is low (40.9%) and increasing participation could reduce morbidity and mortality associated with CRC.
View Article and Find Full Text PDFBackground: Increasing participation in the Australian National Bowel Cancer Screening Program (NBCSP) is the most efficient and cost-effective way of reducing mortality associated with colorectal cancer by detecting and treating early-stage disease. Currently, only 44% of Australians aged 50-74 years complete the NBCSP. This efficacy trial aims to test whether this SMS intervention is an effective method for increasing participation in the NBCSP.
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