Differential effects of aging on NMDA receptors in the intermediate versus the dorsal hippocampus.

There are discrepancies in the literature about the effects of aging on NMDA receptor expression in the hippocampus. The present study was designed to determine whether there are regional differences in how NMDA receptors are affected by aging. Brains from male C57BL/6 mice from three different age groups (3, 10, and 30 months of age) were sectioned coronally through the dorsal hippocampus and horizontally through the intermediate hippocampus.

Comparison of opioid and alpha-2 adrenergic receptor binding in horse and dog brain using radioligand autoradiography.

Objective: To test the hypothesis that the distribution, density, and subtype of opioid and alpha (alpha)-2 adrenergic receptors within the central nervous system (CNS) are significantly different between horse and dog.

Study Design: Prospective experimental study.

Animals: Three dogs (3 years of age) and three horses (2-5 years of age).