Use of Fatigue Index as a Measure of Local Muscle Fatigability in Ryanodine Receptor Isoform-1-Related Myopathies.

Individuals affected with ryanodine receptor isoform-1-related myopathies (RM) commonly experience fatigability in the quadriceps, which may limit physical function and potentially diminish quality of life. Fatigability, in -RM, results from skeletal muscle injury secondary to dysfunction of the major skeletal muscle Ca channel. However, during fatigability testing, affected individuals did not always reach the point of local muscle fatigue as defined by a fatigue index (FATI) at 50% of peak torque.

A Novel Method of Analysis for Prolonged-Standing Data: Accounting for Joint and Muscle Discomfort.

Background: The typical American worker spends about two-thirds of their work day standing. Prolonged standing has been found to be associated with acute and chronic adverse health outcomes. There is considerable variability among existing methods of analysis for prolonged-standing data, and therefore difficulty interpreting and comparing results across studies.