The impact of carboplatin and toceranib phosphate on serum vascular endothelial growth factor (VEGF) and metalloproteinase-9 (MMP-9) levels and survival in canine osteosarcoma.

In this pilot study, 10 dogs with osteosarcoma (OSA) were treated with amputation and subsequent carboplatin chemotherapy (300 mg/m IV q3wk × 4 doses) followed by toceranib phosphate (2.75 mg/kg PO q48h starting at day 14 post carboplatin). Monthly clinical monitoring and serum measurements of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were acquired.

Assessment of the prevalence and clinical features of cryptogenic epilepsy in dogs: 45 cases (2003-2011).

Objective: To determine the prevalence and clinical features of cryptogenic epilepsy among dogs.

Design: Retrospective case series.

Animals: 214 client-owned dogs with onset of epileptic seizures at ≥ 7 years of age.

Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses.

Objective: To measure pharmacokinetics of levetiracetam (LEV) after single-dose oral administration in healthy dogs and determine whether pharmacokinetics changed after repeated oral dosing.

Animals: 6 healthy adult dogs.

Procedures: Pharmacokinetics were calculated following administration of a single dose (mean, 21.

Pharmacokinetics of voriconazole after oral administration of single and multiple doses in African grey parrots (Psittacus erithacus timneh).

Objective: To determine the pharmacokinetics and safety of orally administered voriconazole in African grey parrots.

Animals: 20 clinically normal Timneh African grey parrots (Psittacus erithacus timneh).

Procedures: In single-dose trials, 12 parrots were each administered 6, 12, and 18 mg of voriconazole/kg orally and plasma concentrations of voriconazole were determined via high-pressure liquid chromatography.

A model for improving student confidence and experience in diagnostic sample collection and interpretation.

Confidence and proficiency in diagnosing and treating a variety of diseases is of obvious importance to veterinary students. Traditional teaching methods relying on live-animal laboratories or teaching-hospital cases may not provide the breadth and depth of experience necessary to promote optimal development of confidence and skills. These settings also raise concerns about expense, about animal welfare when animals are used in teaching laboratories, and about the stress and potential risks associated with client-owned pets in the teaching hospital.