Reaching and stepping respond differently to medication and cueing in Parkinson's disease.

The basal ganglia contribute to internal timekeeping, and dopaminergic medication has been observed to moderate timing deficits associated with Parkinson's Disease (PD) during single joint movements. However, it is unclear whether similar effects can be observed in multi-joint movements. Twenty-five people with PD and twelve healthy peers performed repetitive reaching and stepping-in-place tasks with and without auditory cues at their self-selected maximal cadence.

Smartwatch-Based Prediction of Single-Stride and Stride-to-Stride Gait Outcomes Using Regression-Based Machine Learning.

Spatiotemporal variability during gait is linked to fall risk and could be monitored using wearable sensors. Although many users prefer wrist-worn sensors, most applications position at other sites. We developed and evaluated an application using a consumer-grade smartwatch inertial measurement unit (IMU).

Effects of a biomechanical-based Tai Chi program on gait and posture in people with Parkinson's disease: study protocol for a randomized controlled trial.

Background: Parkinson's disease (PD) is associated with changes in gait and posture, which increases the rate of falls and injuries in this population. Tai Chi (TC) training enhances the movement capacity of patients with PD. However, the understanding of the effect of TC training on gait and postural stability in PD is lacking.

Barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty: a qualitative study.

Background: Older adults with frailty are at an increased risk of adverse outcomes after surgery. Exercise before surgery (exercise prehabilitation) may reduce adverse events and improve recovery after surgery. However, adherence with exercise therapy is often low, especially in older populations.

Joint behaviour during arm swing changes with gait speed and predicts spatiotemporal variability and dynamic stability in healthy young adults.

Background: Arm swing is linked to gait stability. How this is accomplished is unclear as most investigations artificially manipulate arm swing amplitude and examine average patterns. Biomechanical evaluation of stride-to-stride upper limb behaviour across a range of gait speeds, where the arm swings as preferred, could clarify this link.

Transcranial Direct Current Stimulation Over Motor Areas Improves Reaction Time in Parkinson's Disease.

Background: Transcranial direct current stimulation (tDCS) has been shown to modulate cortical motor excitability and improve bradykinesia symptoms in Parkinson's disease. It is unclear how targeting different cortical motor areas with tDCS may differentially influence upper limb function for individuals diagnosed with PD.

Objective: This study investigated whether anodal tDCS applied separately to the primary motor cortex and the supplementary motor area would improve upper limb function for individuals with Parkinson's disease.

Home-based prehabilitation with exercise to improve postoperative recovery for older adults with frailty having cancer surgery: the PREHAB randomised clinical trial.

Background: Frailty is a state of vulnerability as a result of decreased reserves. Prehabilitation may increase reserve and improve postoperative outcomes. Our objective was to determine if home-based prehabilitation improves postoperative functional recovery in older adults with frailty having cancer surgery.

Sensitivity of discrete symmetry metrics: Implications for metric choice.

Gait asymmetry is present in several pathological populations, including those with Parkinson's disease, Huntington's disease, and stroke survivors. Previous studies suggest that commonly used discrete symmetry metrics, which compare single bilateral variables, may not be equally sensitive to underlying effects of asymmetry, and the use of a metric with low sensitivity could result in unnecessarily low statistical power. The purpose of this study was to provide a comprehensive assessment of the sensitivity of commonly used discrete symmetry metrics to better inform design of future studies.

Prediction of Freezing of Gait in Parkinson's Disease Using Unilateral and Bilateral Plantar-Pressure Data.

Background: Freezing of gait (FOG) is an intermittent walking disturbance experienced by people with Parkinson's disease (PD). FOG has been linked to falling, injury, and overall reduced mobility. Wearable sensor-based devices can detect freezes already in progress and provide a cue to help the person resume walking.

Walking on Mild Slopes and Altering Arm Swing Each Induce Specific Strategies in Healthy Young Adults.

Slopes are present in everyday environments and require specific postural strategies for successful navigation; different arm strategies may be used to manage external perturbations while walking. It has yet to be determined what impact arm swing has on postural strategies and gait stability during sloped walking. We investigated the potentially interacting effects of surface slope and arm motion on gait stability and postural strategies in healthy young adults.

Increased Arm Swing and Rocky Surfaces Reduces Postural Control in Healthy Young Adults.

Fall-induced injuries can stem from a disruption in the postural control system and place a financial burden on the healthcare system. Most gait research focused on lower extremities and neglected the contribution of arm swing, which have been shown to affect the movement of the center of mass when walking. This study evaluated the effect of arm swing on postural control and stability during regular and rocky surface walking.

Prediction and detection of freezing of gait in Parkinson's disease from plantar pressure data using long short-term memory neural-networks.

Background: Freezing of gait (FOG) is a walking disturbance in advanced stage Parkinson's disease (PD) that has been associated with increased fall risk and decreased quality of life. Freezing episodes can be mitigated or prevented with external intervention such as visual or auditory cues, activated by FOG prediction and detection systems. While most research on FOG detection and prediction has been based on inertial measurement unit (IMU) and accelerometer data, plantar-pressure data may capture subtle weight shifts unique to FOG episodes.

Validity and Sensitivity of an Inertial Measurement Unit-Driven Biomechanical Model of Motor Variability for Gait.

Motor variability in gait is frequently linked to fall risk, yet field-based biomechanical joint evaluations are scarce. We evaluated the validity and sensitivity of an inertial measurement unit (IMU)-driven biomechanical model of joint angle variability for gait. Fourteen healthy young adults completed seven-minute trials of treadmill gait at several speeds and arm swing amplitudes.

Effects of arm swing amplitude and lower limb asymmetry on motor variability patterns during treadmill gait.

Motor variability is a fundamental feature of gait. Altered arm swing and lower limb asymmetry (LLA) may be contributing factors having been shown to affect the magnitude and dynamics of variability in spatiotemporal and trunk motion. However, the effects on lower limb joints remain unclear.

Grouping successive freezing of gait episodes has neutral to detrimental effect on freeze detection and prediction in Parkinson's disease.

Freezing of gait (FOG) is an intermittent walking disturbance experienced by people with Parkinson's disease (PD). Wearable FOG identification systems can improve gait and reduce the risk of falling due to FOG by detecting FOG in real-time and providing a cue to reduce freeze duration. However, FOG prediction and prevention is desirable.

Transcranial direct current stimulation of supplementary motor area improves upper limb kinematics in Parkinson's disease.

Objective: Bradykinesia, defined as slowness of movements, is among the most functionally debilitating symptoms of Parkinson's disease (PD). Hypoactivation of cortical neurons in supplementary motor area (SMA) has been linked to the progression of bradykinesia symptoms. This study investigated the influence of transcranial direct current stimulation (tDCS) applied over SMA on upper limb movement for individuals diagnosed with PD.

Recovery of dynamic stability during slips unaffected by arm swing in people with Parkinson's Disease.

The arm elevation strategy assists in recovering stability during slips in healthy young and elderly individuals. However, in people with Parkinson's Disease, one of the main motor symptoms affecting the upper limbs is reduced arm swing which intensifies throughout the course of the disease before becoming absent. This holds direct implications for these individuals when encountering slips as the arm elevation strategy is an integral component in the interlimb slip response to restore stability.

Early Detection of Freezing of Gait during Walking Using Inertial Measurement Unit and Plantar Pressure Distribution Data.

Freezing of gait (FOG) is a sudden and highly disruptive gait dysfunction that appears in mid to late-stage Parkinson's disease (PD) and can lead to falling and injury. A system that predicts freezing before it occurs or detects freezing immediately after onset would generate an opportunity for FOG prevention or mitigation and thus enhance safe mobility and quality of life. This research used accelerometer, gyroscope, and plantar pressure sensors to extract 861 features from walking data collected from 11 people with FOG.

Boxing with Parkinson's Disease: findings from a qualitative study using self-determination theory.

Purpose: Adults with Parkinson's disease (PD) experience debilitating symptoms that may be mitigated by boxing. Yet, attrition from boxing programs is problematic. Understanding whether PD-specific boxing programs can enhance motivation to remain physically active is important.

Regularity of kinematic data between single and dual-task treadmill walking in people with Parkinson's disease.

Background: Regularity, quantified by sample entropy (SampEn), has been extensively used as a gait stability measure. Yet, there is no consensus on the calculation process and variant approaches, e.g.

Restricted Arm Swing in People With Parkinson's Disease Decreases Step Length and Time on Destabilizing Surfaces.

Fall rates in people with Parkinson's Disease range between 35 and 68% with the majority of falls occurring while walking. Initial evidence suggests that when walking without arm swing, people with Parkinson's Disease adapt their stepping foot placement as a means to preserve dynamic stability. However, it remains unexamined what arm swing's effect has on dynamic stability when walking on destabilizing surfaces.

Selection of Plantar-Pressure and Ankle-Acceleration Features for Freezing of Gait Detection in Parkinson's Disease using Minimum-Redundancy Maximum-Relevance.

Freezing of gait (FOG) is a major hindrance to daily mobility and can lead to falling in people with Parkinson's disease. While wearable accelerometers and gyroscopes have been commonly used for FOG detection, foot plantar pressure distribution could also be considered for this application, given its usefulness in previous gait-based classification. This research examined 325 plantar-pressure based features and 132 acceleration-based features extracted from the walking data of five males with Parkinson's disease who experienced FOG.

Prediction of Freezing of Gait in Parkinson's Disease from Foot Plantar-Pressure Arrays using a Convolutional Neural Network.

Freezing of gait (FOG) is a sudden cessation of locomotion in advanced Parkinson's disease (PD). A FOG episode can lead to falls, decreased mobility, and decreased overall quality of life. Prediction of FOG episodes provides an opportunity for intervention and freeze prevention.

Estimating upper extremity joint loads of persons with spinal cord injury walking with a lower extremity powered exoskeleton and forearm crutches.

Lower extremity powered exoskeletons with crutch support can provide upright mobility to persons with complete spinal cord injury (SCI); however, crutch use for balance and weight transfer may increase upper extremity (UE) joint loads and injury risk. This research presented the first exoskeleton-human musculoskeletal model to estimate upper extremity biomechanics, driven by 3D motion data of persons with complete SCI walking with an exoskeleton and crutch assistance. Forearm crutches instrumented with strain gauges, force plates, and a 3D motion capture system were used to collect kinematic and kinetic data from five persons with complete SCI while walking with the ARKE exoskeleton.

Absent Arm Swing and Dual Tasking Decreases Trunk Postural Control and Dynamic Balance in People With Parkinson's Disease.

Falling during walking is a common occurrence in people with Parkinson's disease and is closely associated with severe social and medical consequences. Recent evidence demonstrates that arm swing affects dynamic balance in healthy young adults; however, it remains unexamined what its effect is in people with Parkinson's disease, particularly when combined with a secondary dual task. Twenty people with Parkinson's disease (63.