Publications by authors named "Julie Metras"
Background: Hereditary adenomatous polyposis syndromes, including familial adenomatous polyposis and other rare adenomatous polyposis syndromes, increase the lifetime risk of colorectal and other cancers.
Methods: A team of 38 experts convened to update the 2008 European recommendations for the clinical management of patients with adenomatous polyposis syndromes. Additionally, other rare monogenic adenomatous polyposis syndromes were reviewed and added.
Some patients with Lynch syndrome (LS) have extreme phenotypes, i.e. cancer before the recommended screening age, or cancer for which there are no screening guidelines.
View Article and Find Full Text PDFArticle Synopsis
- Around 5% of gastric cancers are linked to hereditary cancer syndromes, with specific genes like CDH1 and CTNNA1 causing Hereditary Diffuse Gastric Cancer (HDGC).
- Recent advancements suggest that the risk of developing diffuse gastric cancer is lower than previously believed, with a 30-40% chance, and routine endoscopies can be effective for monitoring instead of immediate surgery.
- Patients with Lynch syndrome and hereditary polyposis have an increased risk for different gastric cancer types, but their main cancer risks are still for colorectal and endometrial cancers.
Data on preimplantation genetic testing (PGT-M) in patients with genetic susceptibility to cancer are scarce in the literature, while there is, in our experience, a growing familiarity with assisted reproduction techniques (ART) among pathogenic variant heterozygotes. We performed a retrospective multicenter study of PGT-M outcomes among French patients with genetic susceptibility to cancer. Our objectives were to collect data on this complex issue, and to help cancer geneticists counsel their patients of reproductive age.
View Article and Find Full Text PDFThe increase in demand for clinical cancer genetics services has impacted the ability to provide services timeously. Given limited resources, this often results in extended appointment waiting times. Over the last 3 years, the Cancer Genetics Service at the National Cancer Centre Singapore has continued to experience a steady increase in demand for its service.
View Article and Find Full Text PDF