Publications by authors named "Julie Maybruck"
Article Synopsis
- Tracking T cell responses is challenging due to limited knowledge of specific TCR sequences and sample size constraints.
- High-throughput TCR sequencing allows the creation of a database from mouse studies, enabling the identification of 315 vaccine-associated TCR sequences (VATS).
- The VATS library proved efficient in distinguishing between naive and vaccinated samples with over 99% accuracy, paving the way for better detection of pathogen-specific TCR sequences in the future.
In a previous study, a new set of Y-chromosome short tandem repeats, the OSU 10-locus set (MPM1 and MPM2), was shown to have a higher discrimination power when evaluated against the 10 SWGDAM loci on a common population panel. Here, we describe the optimization of the multiplex reactions using dye-labeled primers followed by performance evaluations. The loci exhibited high precision, human male specificity, reliability in different body fluids, high sensitivity, stability, and the ability to amplify nonprobative casework and mixture samples.
View Article and Find Full Text PDFA comparative analysis of two Y-STR loci sets was conducted on a population sample of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated the OSU 10-locus set, comprises variable, single copy, male-specific loci that are dispersed across the Y-chromosome. Parallel evaluations were performed using the 10 Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the SWGDAM Y-STR loci.
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