Publications by authors named "Julie Le Bris"
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota.
NPJ Biofilms Microbiomes
September 2024
Article Synopsis
- * Research investigated how bacteria might develop resistance to AF, focusing on the role of the thioredoxin reductase enzyme (TrxB) and its multiple forms in clinical strains, though the number of TrxB genes didn't affect AF's minimum inhibitory concentration (MIC).
- * Mutations that arose after long-term exposure to AF were found in an anti-sigma factor, impacting bacterial physiology, and AF was shown to have a lesser effect on human gut microbiota compared to the antibiotic vancomycin.
Bacterial evolution is affected by mobile genetic elements like phages and conjugative plasmids, offering new adaptive traits while incurring fitness costs. Their infection is affected by the bacterial capsule. Yet, its importance has been difficult to quantify because of the high diversity of confounding mechanisms in bacterial genomes such as anti-viral systems and surface receptor modifications.
View Article and Find Full Text PDFIntroduction: The operon encodes proteins responsible for the esterification of positively charged D-alanine on the wall teichoic acids and lipoteichoic acids of Gram-positive bacteria. This structural modification of the bacterial anionic surface in several species has been described to alter the physicochemical properties of the cell-wall. In addition, it has been linked to reduced sensibilities to cationic antimicrobial peptides and antibiotics.
View Article and Find Full Text PDF