Publications by authors named "Julie K Olsson"
Purpose: Trials of tocilizumab in patients with severe COVID-19 pneumonia have demonstrated mixed results, and the role of tocilizumab in combination with other treatments is uncertain. Here we evaluated whether tocilizumab plus remdesivir provides greater benefit than remdesivir alone in patients with severe COVID-19 pneumonia.
Methods: This randomized, double-blind, placebo-controlled, multicenter trial included patients hospitalized with severe COVID-19 pneumonia requiring > 6 L/min supplemental oxygen.
Article Synopsis
- Lebrikizumab, an anti-IL-13 monoclonal antibody, was evaluated in the CLAVIER study for its effects on airway inflammation and remodeling in patients with moderate-to-severe uncontrolled asthma.
- The study involved a randomized double-blind treatment of 31 patients receiving lebrikizumab and 33 receiving a placebo, assessing changes in eosinophil levels and airway characteristics before and after 12 weeks.
- Results showed that while lebrikizumab did not significantly reduce subepithelial eosinophil counts, it led to improved lung function, reduced subepithelial collagen thickness, and was well-tolerated by patients.
Hospital characteristics associated with timeliness of care in veterans with lung cancer.
Am J Respir Crit Care Med
April 2009
Rationale: Timeliness is one of six important dimensions of health care quality recognized by the Institute of Medicine.
Objectives: To evaluate timeliness of lung cancer care and identify institutional characteristics associated with timely care within the Veterans Affairs (VA) health care system.
Methods: We used data from a VA nation-wide retrospective chart review and an independent audit of VA cancer programs to examine the association between time to first treatment and potentially explanatory institutional characteristics (e.
Background: Timeliness is an important dimension of quality of care for patients with lung cancer.
Methods: We reviewed the records of consecutive patients in whom non-small cell lung cancer (NSCLC) had been diagnosed between January 1, 2002, and December 31, 2003, at the Veterans Affairs Palo Alto Health Care System. We used multivariable statistical methods to identify independent predictors of timely care and examined the effect of timeliness on survival.
Surgical and interventional therapies for pulmonary arterial hypertension.
Semin Respir Crit Care Med
August 2005
Surgical and interventional therapies for pulmonary arterial hypertension (PAH) in appropriately selected patients have the potential to dramatically improve or, in some cases, cure PAH. These include atrial septostomy, a palliative procedure or bridge to transplantation in patients with refractory right heart failure, pulmonary thromboendarterectomy for pulmonary hypertension associated with chronic thromboembolic disease, and closure of congenital systemic-pulmonary shunts in patients with PAH but without significant pulmonary vascular disease. Lung transplantation should be considered for patients with all forms of PAH who demonstrate advanced or progressive disease.
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