The onset of sudden and intense scrotal pain exposes to several problems when it occurs in a young man in Africa. Among the possible etiologies, testicular torsion is the surgical emergency to rule out, because beyond 6 hours of evolution the functional prognosis of the testicle is concerned. The septic evolution towards a purulent melting, in case of exceeded torsion, is also possible.
View Article and Find Full Text PDFDuring anaerobic digestion (AD) of protein-rich wastewater, ammonium (NH) is released by amino acid degradation. High NH concentrations disturb the AD microbiome balance, leading to process impairments. The sensitivity of the AD microbiome to NH and the inhibition threshold depend on multiple parameters, especially the previous microbial acclimation to ammonium stress.
View Article and Find Full Text PDFPreserving β-cell function during the development of obesity and insulin resistance would limit the worldwide epidemic of type 2 diabetes. Endoplasmic reticulum (ER) calcium (Ca(2+)) depletion induced by saturated free fatty acids and cytokines causes β-cell ER stress and apoptosis, but the molecular mechanisms behind these phenomena are still poorly understood. Here, we demonstrate that palmitate-induced sorcin downregulation and subsequent increases in glucose-6-phosphatase catalytic subunit-2 (G6PC2) levels contribute to lipotoxicity.
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