Preliminary in vivo evaluation of a novel intrasaccular cerebral aneurysm occlusion device.

Objective: Current endovascular technology does not offer a perfect solution for all cerebral aneurysms. Our group has built two versions of a novel aneurysm intrasaccular occlusion device (AIOD) to address the drawbacks associated with current occlusion devices. The objective of the present study was to perform pilot proof of concept in vivo testing of this new AIOD in swine and canines.

CT perfusion in the treatment of a swine model of unilateral renal artery stenosis: validation with microspheres.

Purpose: To assess the feasibility of using current computed tomography (CT) perfusion techniques for evaluating unilateral renal artery stenosis (RAS) with assessment of pre- and posttreatment perfusion and to compare those results against the standard of microsphere injection.

Materials And Methods: Six juvenile swine with surgically created right RAS were examined in a combined angiography-CT suite. CT perfusion, injection of fluorescent microspheres, and digital subtraction angiography were performed before and after release of the stenosis.

Transstenotic pressure gradients: measurement in swine--retrospectively ECG-gated 3D phase-contrast MR angiography versus endovascular pressure-sensing guidewires.

Purpose: To prospectively evaluate the hypothesis that retrospectively electrocardiographically gated phase contrast with vastly undersampled isotropic projection reconstruction (VIPR) magnetic resonance (MR) angiography data sets can be used to measure transstenotic pressure gradients (TSPGs) in vivo.

Materials And Methods: TSPGs were calculated by using phase-contrast VIPR MR angiography data sets; measurements obtained with a pair of endovascular pressure-sensing guidewires served as a reference standard. With institutional animal care and use committee approval, 12 swine underwent surgical creation of stenoses at the left common carotid, right renal, and left external iliac arteries.

Angiographic and histological comparison of canine bifurcation aneurysms treated with first generation matrix and standard GDC coils.

Introduction: It is claimed that bioactive coils induce accelerated and more durable aneurysm healing. Data supporting this claim are quite limited. Our purpose was to compare the angiographic and histological results obtained following treatment with different coil types.

Comparison of platinum and first-generation Matrix coils in under-packed canine side-wall aneurysms: evaluation of progressive thrombosis.

Introduction: There is much speculation in reference to the occurrence and mechanisms of progressive aneurysm occlusion after treatment with bioactive coils. However, to our knowledge, there are no studies documenting the impact on progressive occlusion in aneurysms that are intentionally under-packed.

Methods: A total of 24 experimental side-wall aneurysms were created in canine common carotid arteries.