Cardiogenic oscillations extraction in inductive plethysmography: Ensemble empirical mode decomposition.

The purpose of this study is to investigate the potential of the ensemble empirical mode decomposition (EEMD) to extract cardiogenic oscillations from inductive plethysmography signals in order to measure cardiac stroke volume. First, a simple cardio-respiratory model is used to simulate cardiac, respiratory, and cardio-respiratory signals. Second, application of empirical mode decomposition (EMD) to simulated cardio-respiratory signals demonstrates that the mode mixing phenomenon affects the extraction performance and hence also the cardiac stroke volume measurement.

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation.

We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable.

SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis.

We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions". The project uses state-of-the-art multi-scale simulation methods.