Managing risk at the Tucson Sector of the U.S. Border Patrol.

This article describes a risk analysis used to inform resource allocation at the Tucson Sector of the U.S. Border Patrol, the busiest sector for alien and drug trafficking along the Southwest land border with Mexico.

Variation in within-bone stiffness measured by nanoindentation in mice bred for high levels of voluntary wheel running.

The hierarchical structure of bone, involving micro-scale organization and interaction of material components, is a critical determinant of macro-scale mechanics. Changes in whole-bone morphology in response to the actions of individual genes, physiological loading during life, or evolutionary processes, may be accompanied by alterations in underlying mineralization or architecture. Here, we used nanoindentation to precisely measure compressive stiffness in the femoral mid-diaphysis of mice that had experienced 37 generations of selective breeding for high levels of voluntary wheel running (HR).