Reducing inappropriate antibiotic prescribing for acute uncomplicated bronchitis: a systemwide quality improvement project.

This systemwide quality improvement project examined whether a bundle of antimicrobial stewardship interventions reduced the proportion of inappropriate antibiotic prescriptions in ambulatory encounters for adults with acute uncomplicated bronchitis. There was an overall reduction in the proportion of inappropriate prescriptions from pre- to postinterventions (44.9%-32.

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets.

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and primates. First-in-human clinical studies of recombinant human IL-7 (rhIL-7) provided the opportunity to investigate the effects of IL-7 therapy on lymphocytes in vivo.