Publications by authors named "Julie D De Schutter"
Article Synopsis
- Recent research using single-cell RNA sequencing has revealed five distinct states of oligodendroglial cells, expanding beyond the previously recognized two types: oligodendrocyte precursor cells and oligodendrocytes.
- *This new classification enhances our understanding of oligodendroglia in health and disease, aiding comparisons across studies and different animal models.
- *Standardizing terminology and consolidating findings can help address remyelination failures and improve insights into myelin-related disorders like multiple sclerosis and Alzheimer's disease.*
Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNAseq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing.
View Article and Find Full Text PDFAge-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNA-seq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing.
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