Publications by authors named "Julie Cote-Gravel"
Article Synopsis
- Klebsiella oxytoca is a harmful, gram-negative bacterium that typically lives in the intestines and can lead to infections like antibiotic-associated hemorrhagic colitis in humans.
- The case discussed involves colitis triggered by toxin-producing strains of K. oxytoca that developed in a patient experiencing chronic diarrhea.
- The condition was successfully treated through a procedure known as fecal microbiota transplant, which involves transferring healthy gut bacteria to restore balance.
Staphylococcus aureus is a leading cause of bovine intramammary infections (IMI). Standard antibiotic treatments are not very effective and currently available vaccines lack tangible efficacy. Developing a vaccine formulation for S.
View Article and Find Full Text PDFStaphylococcus aureus is known to produce persistent and chronic infections in both humans and animals. It is recognized that small-colony variants (SCVs), which produce higher levels of biofilm and that are capable of intracellular persistence, contribute to the chronicity or recurrence of infections and that this phenotype is inherent to the pathogenesis process. Prevention of S.
View Article and Find Full Text PDFBovine mastitis affects animal health and welfare and milk production and quality, and it challenges the economic success of dairy farms. Staphylococcus aureus is one of the most commonly found pathogens in clinical mastitis but it also causes subclinical, persistent, and difficult-to-treat intramammary infections. Because of the failure of conventional antibiotic treatments and increasing pressure and concern from experts and consumers over the use of antibiotics in the dairy industry, many attempts have been made over the years to develop a vaccine for the prevention and control of Staph.
View Article and Find Full Text PDFArticle Synopsis
- Staphylococcus aureus is a major cause of bovine intramammary infections (IMIs) leading to chronic mastitis, and current vaccine efforts have struggled due to the bacterium's ability to evade the immune system.
- This study introduces a novel attenuated mutant of S. aureus, created by deleting the hemB gene and inactivating the vraG gene, which makes the mutant less virulent and reduces its ability to cause damage in both bovine and murine models.
- The immunization of mice with this double mutant triggered a strong immune response, indicating its potential as a live-attenuated vaccine component against S. aureus-related mastitis.