Evolution of Episiotomy Incidence and Obstetric Anal Sphincter Injury Over 10 Years: A Mixed-Methods Study.

Objective: To assess the association between the decrease in the use of episiotomy and the incidence of obstetric anal sphincter injuries (OASIS) over a 10-year period and understand their reasons by interviewing obstetricians and midwives.

Design: Mixed-methods study.

Setting: A tertiary university public maternity hospital, Paris, France.

Influence of the maternity unit and region of delivery on episiotomy practice in France: a nationwide population-based study.

Introduction: Our objective was to identify factors associated with episiotomy practice in France, in particular, characteristics of the maternity units and regions of delivery.

Material And Methods: We performed a national cross-sectional population-based study in all French maternity units in 2016 including 9284 women with vaginal delivery. Our outcome was the performance of an episiotomy.

Synthesis of 5'-Thymidine-Conjugated Formylphenylboronic Acids as Potential Lysine Targeting Iminoboronate Reversible Covalent Enzyme Probes.

The design of reversible-covalent molecules to selectively target the ε-amino functionality of lysine residues in enzymes or proteins is a highly desirable goal. Herein, we describe synthetic methodology used to prepare a series of 5'-thymidine-linked formylphenylboronic acids as probes to interrogate sugar nucleotide processing enzymes that recognize thymidine. The first synthetic strategy mitigated the need for protecting group manipulations of thymidine by capitalizing upon the straightforward preparation, isolation, and reactivity of 5'-azidothymidine.

Focal adenomyosis is associated with primary infertility.

Objective: To study the association between adenomyosis and infertility, according to the adenomyosis phenotype as diagnosed by magnetic resonance imaging (MRI).

Design: A single-center, cross-sectional study.

Setting: University hospital-based research center.

Dependent personality disorder and physical abuse.

The aim of this study was to test the hypothesis that the likelihood of physical spousal abuse is increased in dependent personality disorder (DPD) compared to other personality disorders. The sample consisted of 305 subjects consecutively admitted to an outpatient department of legal medicine for physical abuse. Using the Structured Clinical Interview for Disorders, screen questionnaire (SCID-II-SQ), the subjects were divided into three groups: without personality disorders (WPD, N=108), with non-dependent personality disorders (NDPD, N=179) and with DPDs (DPD, N=18).