Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.

Aims/hypothesis: Diabetes is characterised by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process; preventing beta cell loss remains a major unmet need. We have previously shown that serum from eight young healthy male participants who exercised for 8 weeks protected human islets and insulin-producing EndoC-βH1 cells from apoptosis induced by proinflammatory cytokines or the endoplasmic reticulum (ER) stressor thapsigargin.

Recidivism Rates of Treated, Non-Treated and Dropout Adolescent Who Have Sexually Offended: a Non-Randomized Study.

The primary objective of this study was to evaluate the effectiveness of a cognitive-behavioral treatment in reducing recidivism by adolescents who have sexually offended (ASO). A secondary objective was to determine whether typologies based on victim age (child, adult/peer, mixed) and relationship (intrafamilial, extra familial, intra/extra familial) discriminate ASO in terms of response to treatment and recidivism. The sample comprised 327 adolescents 12-18 years old ( = 15.

Concordance and Discordance between Paraphilic Interests and Behaviors: A Follow-Up Study.

Although paraphilic interests represent significant risk factors for recidivism among sexual offenders, little is known about the magnitude of concordance between paraphilic interests and behaviors in the general population. The goal of this follow-up study was to conduct secondary analyses based on a sample of 1040 adults (475 men; 565 women) recruited in the general population. Levels of associations and active concordance (having both interest and experience), passive concordance (having neither interest nor experience), active discordance (having experience without interest) and passive discordance (having interest without experience) between paraphilic interest and corresponding behavior were assessed.

Sexual Knowledge, Desires, and Experience of Adolescents and Young Adults With an Autism Spectrum Disorder: An Exploratory Study.

Although most persons with an Autism Spectrum Disorder (ASD) wish to have romantic and/or sexual relationships, little is known about self-report sexuality of adolescents/young adults with ASD. In this exploratory study, 172 male and female adolescents/young adults (68 with ASD and 104 without ASD) completed an online version of the Sexual Behavior Scale-Third edition. Although many more similarities than differences were observed between the groups for views and desires about romantic relationships (e.

The Prevalence of Paraphilic Interests and Behaviors in the General Population: A Provincial Survey.

Paraphilic sexual interests are defined as unusual or anomalous, but their actual occurrence in nonclinical samples is still unknown. This study looked at desire for and experience of paraphilic behaviors in a sample of adult men and women in the general population. A secondary goal was to compare the results of two survey modes-traditional landline telephone versus online.

Discriminant factors for adolescent sexual offending: On the usefulness of considering both victim age and sibling incest.

Understanding the pathways and circumstances of juvenile sexual offending is of utmost importance. However, juvenile sexual offenders (JSO) represent an especially diverse group of individuals, and several categorizations have been proposed to obtain more homogeneous subgroups. Victim age-based and family relation-based categorizations are particularly promising because they seem theoretically and clinically relevant.

Correlates of recidivism among adolescents who have sexually offended.

The present study investigates the recidivism rates of a sample of 351 male adolescents who sexually offended, and were assessed at an outpatient psychiatric clinic in Montreal, Canada, between 1992 and 2002. The mean age of the participants was 15.8 years (SD=1.

Sexual abuse perpetrated by adult and juvenile females: an ultimate attempt to resolve a conflict associated with maternal identity.

Objective: The purpose of this article is to report the descriptive and phenomenological aspects of adult females (AF) and juvenile females (JF) who sexually abuse children and adolescents. A major focus is to study the relational problems during childhood and adulthood of this specific population and how they echo the relational aspects of their own victimization.

Methodology: Since 1992, clinical and evaluative data were collected from a sample of 13 AF and 15 JF who had committed sexual abuse.