In search of a new class of stable nitroxide: synthesis and reactivity of a peri-substituted N,N-bissulfonylhydroxylamine.

Acyclic bissulfonylnitroxides have never been isolated, and degrade through fragmentation. In an approach to stabilising a bissulfonylnitroxide radical, the cyclic, peri-substituted N,N-bissulfonylhydroxylamine, 2-hydroxynaphtho[1,8-de][1,3,2]dithiazine 1,1,3,3-tetraoxide (1), has been prepared by formal nitrogen insertion into the sulfur-sulfur bond of a sulfinylsulfone, naphtho[1,8-cd][1,2]dithiole 1,1,2-trioxide. The heterocyclic ring of 1 is shown to adopt a sofa conformation by X-ray crystallography, with a pseudo-axial hydroxyl group.

Stereoselective α,α'-annelation reactions of 1,3-dioxan-5-ones.

Pyrrolidine enamines derived from three 1,3-dioxan-5-ones undergo α,α'-annelation reactions with methyl α-(bromomethyl)acrylate to produce bridged 2,4-dioxabicyclo[3.3.1]nonane ring systems with complete stereocontrol.

Thermodynamically controlled cyclisation reactions with double phenylsulfanyl migration.

Enantiomerically enriched C2-symmetric tetrols were synthesised by a route involving a 'self-metathesis' reaction with Grubbs' second-generation ruthenium catalyst; these tetrols produced interesting bicyclic products when rearranged under acidic conditions.

Quality of life for patients with a personality disorder comparison of patients in two settings: an English special hospital and a Dutch TBS clinic.

INTRODUCTION: There are differing approaches to the management of people with a severe personality disorder in the UK and The Netherlands. Few comparative studies exist. This study describes the use of an adapted version of the Lancashire Quality of life profile as a patient based-outcome measure.