Publications by authors named "Julie Bollenbacher"
The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essential for T cell development in both humans and mice and for B cell development in mice. Whereas the transcription factor PU.1 regulates IL-7Ralpha expression in mouse pro-B cells via a GGAA motif, we demonstrate here that GA binding protein (GABP) bound to this site and was essential in the regulation of IL-7Ralpha expression in T cells, where PU.
View Article and Find Full Text PDFSignal transducer and activator of transcription (STAT) proteins are latent transcription factors that mediate a wide range of actions induced by cytokines, interferons, and growth factors. We now report the development of thymic T cell lymphoblastic lymphomas in transgenic mice in which Stat5a or Stat5b is overexpressed within the lymphoid compartment. The rate of lymphoma induction was markedly enhanced by immunization or by the introduction of TCR transgenes.
View Article and Find Full Text PDFArticle Synopsis
- Cytokine signals play a crucial role in the homeostasis of CD8+ memory T cells, but the specific mechanisms were not well understood until now.
- Research shows that mice lacking Stat5 proteins (Stat5a and Stat5b KO) have fewer CD8+ T cells, while mice with additional Stat5 (transgenic mice) have more of these cells due to enhanced cell survival and proliferation.
- The study identifies Stat5 proteins as key regulators in how cytokines influence the balance and maintenance of CD8+ memory T cells, highlighting their importance in immune responses.