Publications by authors named "Julie B Weeks"
Article Synopsis
- The study aimed to understand how mannitol, a drug used during craniotomy surgeries, is processed in the body by comparing its pharmacokinetics between high and low doses.
- Patients were given either 0.5 or 1.0 g/kg of mannitol, and researchers collected blood samples to analyze how the drug distributed and cleared from the system, finding a 3-compartment model to best describe its behavior.
- Results indicated that patient weight and dosage significantly impacted drug distribution and clearance rates, with obese patients experiencing higher than expected plasma concentrations based on current weight-based dosing guidelines.
Objective: We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial.
Methods: One thousand patients with initial World Federation of Neurological Surgeons grades of I to III undergoing clipping of intracranial aneurysms after subarachnoid hemorrhage were randomized to intraoperative normothermia (36 degrees C-37 degrees C) or hypothermia (32.5 degrees C-33.
Background: Manual in-line stabilization (MILS) is recommended during direct laryngoscopy and intubation in patients with known or suspected cervical spine instability. Because MILS impairs glottic visualization, the authors hypothesized that anesthesiologists would apply greater pressure during intubations with MILS than without.
Methods: Nine anesthetized and pharmacologically paralyzed patients underwent two sequential laryngoscopies and intubations, one with MILS and one without, in random order.
Article Synopsis
- The study aimed to determine if high blood sugar levels during surgery increase the risk of long-term brain issues in patients at risk for ischemic brain injury.
- A total of 1000 patients who underwent aneurysm clipping were analyzed for their intraoperative blood glucose levels and later assessed for neurological function three months post-surgery using standard evaluation methods.
- Results showed that patients with blood glucose levels at or above 129 mg/dL had worse cognitive outcomes, while those at 152 mg/dL or higher faced greater deficits in neurologic function, suggesting that higher intraoperative glucose is linked to long-term neurological impairments.
Background: Previous studies have characterized segmental craniocervical motion that occurs during direct laryngoscopy and intubation with a Macintosh laryngoscope blade. Comparable studies with the Miller blade have not been performed. The aim of this study was to compare maximal segmental craniocervical motion occurring during direct laryngoscopy and orotracheal intubation with Macintosh and Miller blades.
View Article and Find Full Text PDFObjective: We hypothesize that subtle neurological signs at baseline could be present in some "good grade" subarachnoid hemorrhage (SAH) patients and that they would have negative prognostic implications.
Methods: We analyzed data from 1000 patients randomized to the Intraoperative Hypothermia for Aneurysm Surgery Trial (World Federation of Neurological Societies Grades I, II, and III). Nine hundred and forty-four patients had a complete National Institutes of Health Stroke Scale (NIHSS) examination performed at baseline.