Publications by authors named "Julie Auffray"
Article Synopsis
- Tablets provide advantages like easy use, cost-effectiveness, and better stability for delivering biopharmaceuticals, allowing for innovative local administration methods.
- This study focuses on developing monoclonal antibodies in tablet form while maintaining their biological function, analyzing the effects of different excipients and processing parameters.
- Results indicate that compressing antibodies at 100 MPa does not harm their binding properties, and the tablets remain stable for 6 months at room temperature, suggesting a promising method for biopharmaceutical delivery.
Pharm Dev Technol
November 2022
Article Synopsis
- Monoclonal antibodies are increasingly important in medicine, but they often have low stability in liquid form, making freeze-drying the preferred method for preserving them.
- The optimization of the freeze-drying process is crucial for meeting quality and safety standards set by regulatory authorities while also reducing time and energy costs.
- This review focuses on recent literature regarding the freeze-drying of monoclonal antibodies, highlighting strategies for improving their stability and optimizing the overall process.
