Randomized open-label trial of intravenous brivaracetam versus lorazepam for acute treatment of increased seizure activity.

Objective: The objective of the present trial was to assess efficacy and safety of intravenous (IV) brivaracetam (BRV) vs. lorazepam (LZP) in patients with epilepsy undergoing evaluation in an epilepsy monitoring unit (EMU) who experienced seizures requiring acute treatment.

Methods: This was a phase 2, open-label, randomized, active-control, proof-of-concept trial (EP0087; NCT03021018).

Validation of the revised Patient Perception of Migraine Questionnaire: measuring satisfaction with acute migraine treatment.

Objective: To evaluate the psychometric properties of the revised Patient Perception of Migraine Questionnaire (PPMQ-R), which measures satisfaction with migraine treatment.

Background: The original version of the PPMQ was developed prior to the introduction of newer migraine treatments, which may have attributes that influence treatment satisfaction.

Methods: Literature review, patient focus groups, and one-on-one patient interviews guided revisions to the original PPMQ.