Publications by authors named "Julie A Swain"
Perioperative management of P2Y12 inhibitors in patients undergoing cardiac surgery within 1 year of PCI.
Eur Heart J Cardiovasc Pharmacother
December 2022
Article Synopsis
- The study aimed to assess how P2Y12 receptor inhibitor therapy affects patients having cardiac surgery within a year of undergoing percutaneous coronary intervention (PCI).
- It analyzed 20,279 PCI patients, finding that only a small percentage (359) had cardiac surgery, with perioperative P2Y12 inhibitor usage not significantly impacting major adverse events or bleeding overall, despite some trends indicating lower heart attack rates.
- However, patients who continued the medication until surgery faced a higher risk of bleeding, and factors like timing from PCI to surgery, heart function, and urgency of the surgery were key predictors of complications.
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices.
View Article and Find Full Text PDFThe VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices.
View Article and Find Full Text PDFSixty-year perspective on coronary artery bypass grafting in women.
J Thorac Cardiovasc Surg
September 2003