The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived, synthetic cannabinoids bind to CB1R, initiating the inhibitory G-protein (G) and the β-arrestin signaling pathways. Within the G signaling pathway, CB1R activates G protein-gated, inwardly-rectifying potassium (GIRK) channels.
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