Synergy Between Filtrates And Voriconazole Against Biofilm Is Less for Mucoid Isolates From Persons With Cystic Fibrosis.

Persons with cystic fibrosis (CF) frequently suffer from and co-infections. There is evidence that co-infections with these interacting pathogens cause airway inflammation and aggravate deterioration of lung function. We recently showed that laboratory isolates synergistically interact with the anti-fungal azole voriconazole (VCZ), inhibiting biofilm metabolism of several laboratory strains.

Metrics of Antifungal Effects of Ciprofloxacin on Planktonic Growth and Biofilm Metabolism; Effects of Iron and Siderophores.

and frequently coexist in the airways of immunocompromised patients or individuals with cystic fibrosis. Ciprofloxacin (CIP) is a synthetic quinolone antibiotic commonly used to treat bacterial infections, such as those produced by CIP binds iron, and it is unclear what effect this complex would have on the mycobiome. The effects of CIP on were dependent on the iron levels present, and on the presence of siderophores.