Publications by authors named "Julianna Rugor"
Rationale: We hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia.
Objective: Preeclamptic pregnancies feature hypertension, proteinuria, and placental anomalies. Feto-placental macrophages regulate villous trophoblast differentiation during placental development.
Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure.
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- - Preeclampsia is a serious pregnancy condition linked to restricted baby growth, thought to be caused by immune system issues, particularly involving T cells.
- - The study tested a treatment called CD28 superagonist to increase regulatory T cells in rats, applying it at different stages of pregnancy, which significantly boosted T cell levels in circulation and placenta.
- - While the treatment didn't affect maternal blood pressure or protein levels, it improved fetal health, leading to heavier pups and better brain development, indicating potential benefits against growth retardation.
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks.
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