Chemically Stable Diazo Peptides as Selective Probes of Cysteine Proteases in Living Cells.

Diazo peptides have been described earlier, however, due to their high reactivity have not been broadly used until today. Here, we report the preparation, properties, and applications of chemically stable internal diazo peptides. Peptidyl phosphoranylidene-esters and amides were found to react with triflyl azide primarily to novel 3,4-disubstituted triazolyl-peptides.

Multi-detector row CT: is prospective electrocardiographic triggering improving the detection of small pulmonary tumors?

Rationale And Objectives: To compare prospectively ECG-triggered multi-detector row computed tomography (ECG-MDR-CT) and multi-detector row computed tomography (MDR-CT) without triggering for the detection of pulmonary tumors.

Materials And Methods: 100 patients with proven or suspected tumors were referred for CT of the lung for staging of lung metastases. First, a non-enhanced scan was performed using prospective ECG-triggering on a four-row multidetector helical CT scanner, followed by a contrast-enhanced scan without triggering.