Publications by authors named "Juliane Rossato"
In acute myocardial infarction (AMI), reactive oxygen species may cause irreversible damage to the heart tissue. Physical training is capable of enhancing antioxidant capacity, acting as a cardioprotective factor. We assessed the preventive effects of physical training on the antioxidant and functional responses of the heart of Wistar Kyoto rats after AMI.
View Article and Find Full Text PDFThe vascular endothelium plays a key role in arterial wall homeostasis by preventing atherosclerotic plaque formation. A primary causal factor of endothelial dysfunction is the reactive oxygen species. Aerobic exercise is ascribed as an important adjuvant therapy in endothelium-dependent cardiovascular disease.
View Article and Find Full Text PDFArticle Synopsis
- Regular moderate physical activity benefits the immune system, enhancing infection resistance and inhibiting cancer growth, although the mechanisms behind this are not fully understood.
- In a study, sedentary rats showed significant increases in macrophage function after an acute swimming session, including a 2.4-fold rise in phagocytosis and a 95.5% increase in nitrite production.
- The exercise activated the expression of NOS-2 (an important enzyme related to immune response) without causing systemic oxidative stress or indicating stress in immune cells, suggesting local factors are involved in this activation.
Article Synopsis
- Striated muscle activity contributes to oxidative stress (OxStress), and while the intensity and duration of exercise can create a redox imbalance, the heart seems to resist significant damage from OxStress due to its unique protective mechanisms.
- Antioxidant strategies alone have been mostly ineffective in preventing cellular injury, suggesting that additional protective mechanisms may exist, particularly involving multidrug resistance-associated proteins (MRP).
- A study on Wistar rats revealed that MRP1 expression is induced in the heart in response to exercise but is absent in skeletal muscle, while the heat shock protein HSP70 shows different expression patterns, indicating complex responses to exercise-induced OxStress between heart and skeletal muscles.