Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice.

Background: Endothelin 1 contributes to renal blood flow control and pathogenesis of kidney diseases. The differential effects, however, of endothelin 1 (ET-1) on afferent (AA) and efferent arterioles (EA) remain to be established.

Methods: We investigated endothelin type A and B receptor (ETA-R, ETB-R) functions in the control of AA and EA.