Publications by authors named "Juliane Lauks"
Emergency Departments (ED) are trying to alleviate crowding using various interventions. We assessed the effect of an alternative model of care, the Medical Team Evaluation (MTE) concept, encompassing team triage, quick registration, redesign of triage rooms and electronic medical records (EMR) on door-to-doctor (waiting) time and ED length of stay (LOS). We conducted an observational, before-and-after study at an urban academic tertiary care centre.
View Article and Find Full Text PDFArticle Synopsis
- The SNARE protein vti1a is crucial for the generation of secretory vesicles and the trafficking of calcium channels, but it is not directly involved in the final fusion process for neurotransmitter release in adrenal chromaffin cells.
- Research shows that vti1a is located near the trans-Golgi network rather than in mature secretory vesicles, and its absence leads to fewer and smaller vesicles, which hampers exocytosis.
- Re-expressing vti1a over a long period is necessary to restore the secretory function, highlighting its role in preparing vesicles rather than facilitating their fusion.
Article Synopsis
- * Neurons without the Neurobeachin (Nbea) protein show significantly reduced synaptic responses due to decreased levels of critical receptors like glutamate and GABA(A) at the synapse.
- * Nbea is essential for the transport of specific receptor types to synapses, as its absence leads to immature AMPA receptor accumulation and prevents mature receptors from reaching their synaptic locations, while other membrane proteins remain unaffected.
Neurobeachin (Nbea) is a multidomain scaffold protein abundant in the brain, where it is highly expressed during development. Nbea-null mice have severe defects in neuromuscular synaptic transmission resulting in lethal paralysis of the newborns. Recently, it became clear that Nbea is important also for the functioning of central synapses, where it is suggested to play a role in trafficking membrane proteins to both, the pre- and post-synaptic sites.
View Article and Find Full Text PDF