Structure and function of dual-source cholinergic modulation in early vision.

Behavioral states such as arousal and attention have profound effects on sensory processing, determining how-even whether-a stimulus is perceived. This state-dependence is believed to arise, at least in part, in response to inputs from subcortical structures that release neuromodulators such as acetylcholine, often nonsynaptically. The mechanisms that underlie the interaction between these nonsynaptic signals and the more point-to-point synaptic cortical circuitry are not well understood.

Links between temporal acuity and multisensory integration across life span.

The temporal relationship between individual pieces of information from the different sensory modalities is one of the stronger cues to integrate such information into a unified perceptual gestalt, conveying numerous perceptual and behavioral advantages. Temporal acuity, however, varies greatly over the life span. It has previously been hypothesized that changes in temporal acuity in both development and healthy aging may thus play a key role in integrative abilities.

Adult plasticity of spatiotemporal receptive fields of multisensory superior colliculus neurons following early visual deprivation.

Purpose: Previous work has established that the integrative capacity of multisensory neurons in the superior colliculus (SC) matures over a protracted period of postnatal life (Wallace and Stein, 1997), and that the development of normal patterns of multisensory integration depends critically on early sensory experience (Wallace et al., 2004). Although these studies demonstrated the importance of early sensory experience in the creation of mature multisensory circuits, it remains unknown whether the reestablishment of sensory experience in adulthood can reverse these effects and restore integrative capacity.

Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions.

Previous work has established that the spatial receptive fields (SRFs) of multisensory neurons in the cerebral cortex are strikingly heterogeneous, and that SRF architecture plays an important deterministic role in sensory responsiveness and multisensory integrative capacities. The initial part of this contribution serves to review these findings detailing the key features of SRF organization in cortical multisensory populations by highlighting work from the cat anterior ectosylvian sulcus (AES). In addition, we have recently conducted parallel studies designed to examine SRF architecture in the classic model for multisensory studies, the cat superior colliculus (SC), and we present some of the preliminary observations from the SC here.