Impact of different types of resuscitation fluids on coagulation and continuous venovenous hemofiltration hemocompatibility in a porcine model.

Intensive therapy demanding diseases (organ failure or sepsis) are assumed to be the etiology behind a decreased biocompatibility of extracorporeal systems for renal replacement therapy (RRT). There are also potential interactions between different components of the overall therapy. Volume substitutes are known to influence hemorheology and coagulation.

Evaluation of a new large animal model for controlled intracranial pressure changes induced by capnoperitoneum.

Background: A standardized large animal model for controlled ICP manipulation within a relevant range and repetitive ICP measurements is missing. We sought to develop such a model on the base of controlled IPP changes induced by capnoperitoneum.

Methods: We utilized six female pigs (mean body weight 59.

Influence of different heparin concentrations on the results of in vitro investigations in plasmaseparation technology using capillary membrane filters.

Capillary membrane filters are devices commonly used for plasmapheresis and recirculating detoxification systems, including plasmaseparation units. Besides clinical trials and case reports, research on plasmafiltration techniques is carried out using in vitro systems. Notably, such hemoperfused in vitro systems require anticoagulation protocols suitable for investigating the clearance performance and hemocompatibility of a plasmafilter.