Publications by authors named "Juliane Kager"
Background: Liver biopsies to determine the cause of unclear hepatopathy and acute liver failure represent a diagnostic hallmark and require close cooperation between clinicians and pathologists. The commonly acute presentation of hepatic dysfunction warrants a rapid diagnosis. Infectious causes of hepatitis may be identified by the pathologist, supporting further diagnostic and therapeutic steps.
View Article and Find Full Text PDFHuman adenovirus (HAdV) can often lead to fulminant hepatitis in immunocompromised patients, mostly after reactivation of HAdV. Different risk factors, e.g.
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- Scientists are trying to figure out if the gut microbiome (the tiny bacteria in our stomachs) affects COVID-19 or if COVID-19 affects the microbiome, but it's really complicated to study.
- In a study, they looked at samples from people with COVID-19 and noticed that bacteria in their gut and mouth changed depending on how sick they were.
- They discovered that having certain bacteria could help predict how well someone would do with COVID-19, and a stable gut microbiome might lead to a better recovery.
The clinical and immunological impact of B-cell depletion in the context of coronavirus disease 2019 (COVID-19) is unclear. We conducted a prospectively planned analysis of COVID-19 in patients who received B-cell depleting anti-CD20 antibodies and chemotherapy for B-cell lymphomas. The control cohort consisted of age- and sex-matched patients without lymphoma who were hospitalized because of COVID-19.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry.
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- The study investigates the link between iron metabolism and cardiovascular disease, revealing that hereditary haemochromatosis is associated with lower cardiovascular risk despite iron imbalances.* -
- Analysis of genetic data showed that variations in the HFE gene lower LDL cholesterol levels in humans, and similar effects were observed in mice lacking the Hfe gene, leading to reduced atherosclerosis.* -
- The researchers identified a mechanism where HFE negatively regulates LDL receptor expression in liver cells and highlighted the role of liver-resident Kupffer cells in cholesterol homeostasis, suggesting new treatment avenues for cholesterol-related issues.*