Renal proteome in mice with different susceptibilities to fluorosis.

A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis due to their genetic backgrounds. They also differ with respect to several features of fluoride (F) metabolism and metabolic handling of water. This study was done to determine whether differences in F metabolism could be explained by diversities in the profile of protein expression in kidneys.

Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride.

Objective: This study evaluated the use of plasma, bone surface (periosteal) and whole bone as biomarkers of chronic fluoride (F) exposure.

Methods: Forty male Wistar rats were assigned to 4 groups (n=10/gr) that differed according to the F concentration they received in the drinking water. Groups 1, 2, 3 and 4 received water containing 0 (control), 5, 15, and 50 mg F/L, respectively.

Bone surface and whole bone as biomarkers for acute fluoride exposure.

This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F administration.

[Comparison of 2 techniques for enamel remineralization].

Six patients enrolled at the Hospital of Rehabilitation of Craniofacial Anomalies, University of São Paulo, aging 16 to 20 years, were selected. All patients presented with white spots in both sides of the superior arch, which totalized 41 spots. The left side of the arch was submitted to remineralization by means of the conventional technique with Reminer, a commercially available product.