Publications by authors named "Juliana da Silva Jezuino"
Aims: This study aimed to evaluate the short- and long-term adverse effects of blood pressure (BP), vascular endothelial function, and estrogen receptor (ERα and ERβ) modulation on endothelial function in female Wistar rats treated with topiramate (TPM), an antiepileptic drug, during the peripubertal period.
Materials And Methods: Female Wistar rats were treated with TPM (41 mg/kg) or water (CTR group) by gavage from postnatal day (PND) 28 to 50 (peripubertal phase). At the end of the treatment, the TPM and CTR rats were divided into two groups and evaluated after 24 h or from PND 85 (adulthood).
Article Synopsis
- Protein restriction during the peripubertal period (ages 30-60 days in rats) was studied to see if it leads to endothelial dysfunction later in adulthood.
- Male Wistar rats were fed either a normal protein diet (23%) or a low protein diet (4%) and then their aorta responses were tested when they reached maturity (age 120 days).
- Results indicated that low protein intake was linked to increased sensitivity to phenylephrine (a vasoconstrictor) and higher oxidative stress markers, suggesting that early protein restriction can negatively affect vascular health in adulthood.