Publications by authors named "Juliana Swiokla"
Aim: Determine the role of calcitonin-gene related peptide in promoting post-traumatic headache and dysregulation of central pain modulation induced by mild traumatic brain injury in mice.
Methods: Mild traumatic brain injury was induced in lightly anesthetized male C57BL/6J mice by a weight drop onto a closed and unfixed skull, which allowed free head rotation after the impact. We first determined possible alterations in the diffuse noxious inhibitory controls, a measure of net descending pain inhibition called conditioned pain modulation in humans at day 2 following mild traumatic brain injury.
Article Synopsis
- Migraine pain may be linked to the activation of specific receptors (protease activated receptor 2) on dural mast cells and trigeminal nociceptors, potentially making these receptors targets for new migraine treatments.
- A study introduced PAR650097, a monoclonal antibody targeting protease activated receptor 2, and assessed its effectiveness in animal models for preventing migraine-triggering pain mechanisms.
- Results showed that PAR650097 quickly interacted with the target receptor and demonstrated potential for preventing pain elicited by various migraine triggers, outperforming traditional treatments like fremanezumab.
Aim: Development and characterization of a novel injury-free preclinical model of migraine-like pain allowing mechanistic assessment of both acute and preventive treatments.
Methods: A "two-hit" hyperalgesic priming strategy was used to induce vulnerability to a normally subthreshold challenge with umbellulone, a transient receptor potential ankyrin 1 (TRPA1) activator, in uninjured female and male C57BL/6 mice. Priming (i.
Objective: Pharmacological evaluation of the mu-opioid receptor (MOR) agonist properties of NKTR-181 in rodent models.
Methods: Graded noxious stimulus intensities were used in rats to establish the antinociceptive potency and efficacy of NKTR-181 relative to morphine, fentanyl, and oxycodone. Characteristics of MOR agonist actions, as measured by antinociceptive tolerance and cross-tolerance, as well as opioid-induced hyperalgesia (OIH) and naloxone-precipitated withdrawal in NKTR-181- and morphine-dependent in mice, were compared.
Aim: Evaluation of cannabinoid receptor agonists in a preclinical model of medication overuse headache.
Methods: Female Sprague Dawley rats received graded intraperitoneal doses of WIN55,212-2 or Δ-9-tetrahydrocannabinol (Δ-9-THC). Antinociception (tail-flick test), catalepsy and hypomotility (open field test) and impairment of motor function (rotarod test) were assessed to establish effective dosing.