Publications by authors named "Juliana Sanchez-Posada"

Article Synopsis
  • Accurate diagnosis and treatment of complex cardiac tumors is challenging, especially for surgical resection, but 3D reconstruction and printing can enhance pre-operative planning and care.
  • The study reports two patients with rare cardiac conditions, one with cardiac angiosarcoma and the other with IgG4-related disease, where 3D models aided in surgical strategies.
  • Both patients experienced successful outcomes, with the angiosarcoma patient receiving chemotherapy and another surgery, while the IgG4 patient had complete tumor resection, demonstrating the utility of 3D printing in surgical planning.
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During heart development, the embryonic ventricle becomes enveloped by the epicardium, which adheres to the outer apical surface of the heart. This is concomitant with onset of ventricular trabeculation, where a subset of cardiomyocytes lose apicobasal polarity and delaminate basally from the ventricular wall. Llgl1 regulates the formation of apical cell junctions and apicobasal polarity, and we investigated its role in ventricular wall maturation.

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Aims: Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionalized cellular changes. While previous studies have demonstrated broad requirements for extracellular matrix (ECM) components in cardiac morphogenesis, we hypothesized that ECM regionalization may fine tune cardiac shape during heart development.

Methods And Results: Using live in vivo light sheet imaging of zebrafish embryos, we describe a left-sided expansion of the ECM between the myocardium and endocardium prior to the onset of heart looping and chamber ballooning.

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