N-Acetylcysteine prevents baker's-yeast-induced inflammation and fever.

Objective And Design: To investigate whether N-acetylcysteine (NAC) alters baker's-yeast-induced fever and inflammation.

Material Or Subjects: Male Wistar rats (26-28 days old) injected with baker's yeast (135 mg/kg, intraperitoneal) or prostaglandin E(2) (300 ng/100 μL, intrathecal).

Treatment: Rats were injected with NAC (500 mg/kg, subcutaneous, or 50 μg/100 μL, intrathecal) 1 h before, or 2 h after, pyrogen injection.

Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.

Objective: To investigate the effect of diacerein, an anti-inflammatory drug, on body temperature and protocols of fever induction in male Wistar rats.

Methods: The effect of diacerein (5.0 mg/kg, s.