Publications by authors named "Juliana Ravelli Baldassarre Martins"
Comparison of microRNA Expression Profile in Chronic Myeloid Leukemia Patients Newly Diagnosed and Treated by Allogeneic Hematopoietic Stem Cell Transplantation.
Juliana Ravelli Baldassarre Martins Leonardo Nazario de Moraes Sarah Santiloni Cury Juliane Dadalto Juliana Capannacci
Front Oncol
September 2020
Article Synopsis
- Chronic myeloid leukemia (CML) is caused by a genetic mutation that creates the Philadelphia chromosome, leading to the production of a protein (BCR/ABL1) that promotes cancer cell growth.
- While tyrosine kinase inhibitors are a primary treatment, allogeneic-hematopoietic stem cell transplantation (allo-HSCT) is also important for patients who don't respond to these drugs.
- A study comparing microRNA profiles in CML patients to others revealed significant changes in specific microRNAs, which may play a role in cancer development and could serve as potential biomarkers or targets for future therapies.