Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines: a phase 3, parallel-group study.

Background: In a parallel-group, international, phase 3 study (ClinicalTrials.govNCT04762680), we evaluated prototype (D614) and Beta (B.1.

A Feshbach resonance in collisions between triplet ground-state molecules.

Collisional resonances are important tools that have been used to modify interactions in ultracold gases, for realizing previously unknown Hamiltonians in quantum simulations, for creating molecules from atomic gases and for controlling chemical reactions. So far, such resonances have been observed for atom-atom collisions, atom-molecule collisions and collisions between Feshbach molecules, which are very weakly bound. Whether such resonances exist for ultracold ground-state molecules has been debated owing to the possibly high density of states and/or rapid decay of the resonant complex.

Immunological non-inferiority and safety of a quadrivalent inactivated influenza vaccine versus two trivalent inactivated influenza vaccines in China: Results from two studies.

Who Universal Trial Numbers (utns): U1111-1174-4615 and U1111-1174-4698.

Clinicaltrials.gov: NCT04210349 and NCT03430089.

Immunogenicity and safety of booster CYD-TDV dengue vaccine after alternative primary vaccination schedules in healthy individuals aged 9-50 years: a randomised, controlled, phase 2, non-inferiority study.

Background: Dengue is endemic in many countries throughout the tropics and subtropics, and the disease causes substantial morbidity and health-care burdens in these regions. We previously compared antibody responses after one-dose, two-dose, or three-dose primary regimens with the only approved dengue vaccine CYD-TDV (Dengvaxia; Sanofi Pasteur, Lyon, France) in individuals aged 9 years and older with previous dengue exposure. In this study, we assessed the need for a CYD-TDV booster after these primary vaccination regimens.

Control of reactive collisions by quantum interference.

In this study, we achieved magnetic control of reactive scattering in an ultracold mixture of Na atoms and NaLi molecules. In most molecular collisions, particles react or are lost near short range with unity probability, leading to the so-called universal rate. By contrast, the Na + NaLi system was shown to have only ~4% loss probability in a fully spin-polarized state.

Humoral and cellular immunogenicity and safety following a booster dose of a tetravalent dengue vaccine 5+ years after completion of the primary series in Singapore: 2-year follow-up of a randomized phase II, placebo-controlled trial.

The tetravalent dengue vaccine (CYD-TDV) is approved for use as a 3-dose series for the prevention of dengue in seropositive individuals ≥9 years. A randomized, placebo-controlled, phase II study of a booster dose of CYD-TDV in individuals who completed the 3-dose schedule >5 years previously (NCT02824198), demonstrated that a booster restored neutralizing antibody titers to post-dose 3 levels. We present additional immunogenicity assessments up to 24 months post-booster, and B- and T-cell responses in a participant subset.

Immunogenicity and safety of simplified vaccination schedules for the CYD-TDV dengue vaccine in healthy individuals aged 9-50 years (CYD65): a randomised, controlled, phase 2, non-inferiority study.

Background: Three doses of the licensed tetravalent dengue vaccine CYD-TDV (Dengvaxia, Sanofi Pasteur, Lyon France) are immunogenic and effective against symptomatic dengue in individuals aged 9 years and older who are dengue seropositive. Previous trials have provided some evidence that antibody responses elicited after just one dose or two doses of CYD-TDV might be similar to those elicited after three doses. We compared antibody responses following one-dose, two-dose, and three-dose vaccination regimens in individuals who were dengue seropositive at baseline up to 1 year after the last injection.

Collisional cooling of ultracold molecules.

Since the original work on Bose-Einstein condensation, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics. Ultracold molecules in the micro- and nanokelvin regimes are expected to bring powerful capabilities to quantum emulation and quantum computing, owing to their rich internal degrees of freedom compared to atoms, and to facilitate precision measurement and the study of quantum chemistry. Quantum gases of ultracold atoms can be created using collision-based cooling schemes such as evaporative cooling, but thermalization and collisional cooling have not yet been realized for ultracold molecules.

Immunogenicity and safety of a dengue vaccine given as a booster in Singapore: a randomized Phase II, placebo-controlled trial evaluating its effects 5-6 years after completion of the primary series.

The tetravalent dengue vaccine (CYD-TDV; Dengvaxia®) is administered on a three-dose schedule, 6 months apart in those aged ≥9 years in a number of dengue-endemic countries in Asia and Latin America. In this study, CYD63 (NCT02824198), participants aged 9-45 years at first vaccination, and who had received three doses of CYD-TDV in the CYD28 study more than 5 years previously, were randomized 3:1 to receive a booster CYD-TDV dose (Group 1) or placebo (Group 2). Dengue neutralizing antibody geometric mean titres (PRNT GMTs) for each of the four dengue serotypes were assessed in sera collected before and 28 days after booster injections.

Photoassociation of ultracold NaLi.

We perform photoassociation spectroscopy in an ultracold Na-Li mixture to study the cΣ excited triplet molecular potential. We observe 50 vibrational states and their substructure to an accuracy of 20 MHz, and provide line strength data from photoassociation loss measurements. An analysis of the vibrational line positions using near-dissociation expansions and a full potential fit is presented.

Two-photon spectroscopy of the NaLi triplet ground state.

We employ two-photon spectroscopy to study the vibrational states of the triplet ground state potential (aΣ) of the NaLi molecule. Pairs of Na and Li atoms in an ultracold mixture are photoassociated into an excited triplet molecular state, which in turn is coupled to vibrational states of the triplet ground potential. Vibrational state binding energies, line strengths, and potential fitting parameters for the triplet ground aΣ potential are reported.

Long-Lived Ultracold Molecules with Electric and Magnetic Dipole Moments.

We create fermionic dipolar ^{23}Na^{6}Li molecules in their triplet ground state from an ultracold mixture of ^{23}Na and ^{6}Li. Using magnetoassociation across a narrow Feshbach resonance followed by a two-photon stimulated Raman adiabatic passage to the triplet ground state, we produce 3×10^{4} ground state molecules in a spin-polarized state. We observe a lifetime of 4.