Publications by authors named "Juliana M S Salgado"
Article Synopsis
- A nucleotide repeat expansion (NRE) in the gene's first intron is linked to the most common genetic causes of ALS and FTD.
- Researchers discovered that C9 NRE-containing RNAs can undergo exonization and are exported from the nucleus as various spliced mRNA forms, with increased aberrant splicing observed in affected motor neurons and brain tissues.
- The findings suggest that NREs can trigger abnormal splicing, impacting the production and translation of RNAs, indicating a significant role in these neurodegenerative diseases.
