Publications by authors named "Juliana K Craig"
Cytoreductive nephrectomy became accepted as standard of care for selected patients with metastatic renal cell carcinoma (mRCC) because of improved survival observed in patients treated with cytoreductive nephrectomy in combination with interferon-α in two randomized clinical trials published in 2001. Over the past two decades, novel systemic therapies have shown higher treatment response rates and improved survival outcomes compared with interferon-α. During this rapid evolution of mRCC treatments, systemic therapies have been the primary focus of clinical trials.
View Article and Find Full Text PDFWe evaluated the outcomes of 168 patients undergoing delayed or second autologous stem cell transplant (ASCT) for relapsed multiple myeloma (MM) from 2010 to 2019. Overall, 21% (n = 35) patients had received a prior transplant and 69% (n = 116) underwent transplant at first relapse. Overall, 27% patients had high-risk cytogenetics and 15% had ISS stage III disease.
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- Plasma cell leukemia (PCL) is a rare and aggressive disorder, and the best treatment method, whether using autologous (auto) or allogeneic (allo) stem cell transplantation, is still uncertain due to limited clinical evidence.
- The study analyzed outcomes from 16 PCL patients (14 with primary PCL) who underwent either autoSCT or alloSCT, revealing that after transplantation, patients showed varying degrees of response, with those undergoing alloSCT achieving a complete response more consistently.
- Despite similar survival rates between the two treatment types, with both groups experiencing relapses as the main cause of death, the median overall survival was longer for the alloSCT group, though not
We evaluated 79 patients with multiple myeloma (MM) ≥70 years referred to our blood and marrow transplant clinic, within 1 year of diagnosis from 2010 to 2019, for consideration of autologous stem cell transplant (ASCT). Thirty-eight (48%) of 79 patients underwent ASCT. ASCT was not pursued in 41 (52%) patients due to: patient or physician preference in 80% (n = 33) or ineligibility in 20% (n = 8).
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- The study investigates the role of apoptosis in the development of aortic root aneurysms in Marfan syndrome using a specific mouse model (Fbn1(C1039G/+)).
- Researchers found increased apoptosis in the ascending aorta of these mice, particularly smooth muscle cells, during early aneurysm formation, and treatment with a caspase inhibitor significantly reduced aneurysm size.
- The findings suggest that caspases on the surface of apoptotic smooth muscle cells contribute to the degradation of elastin, potentially exacerbating aneurysm development in Marfan syndrome.