Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis.

Objectives: To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature.

Methods: Altogether, 154 articles were found in four databases.

Melatonin prevents age-related hearing loss in the murin experimental model.

Objective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period.

Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 μL of 10 mg of melatonin/kg/day orally for a 12-month period.

Role of melatonin in prevention of age-related hearing loss.

Introduction: Age-related hearing loss (ARHL) is a consequence of aging of the auditory system. The best known mechanism of cell death in ARHL is apoptosis due to increased production of reactive oxygen species. In this context, it is hypothesized that melatonin, owing to its high antioxidant potential and its action in the mitochondria, helps prevent or delay outer hair cell dysfunction (HCD).

Protective Effect of Melatonin on Cisplatin-induced Ototoxicity in Rats.

Background/aim: Cisplatin is a highly effective chemotherapeutic agent that is used to treat solid tumors; however, its severe side effects remain a limitation. In particular, the high incidence of cisplatin-induced ototoxicity has attracted interest. Melatonin has been shown to decrease the toxic effects of cisplatin due to its antioxidant activity, and could increase the efficacy of cancer chemotherapy.

[Sugarcane biopolymer membrane: experimental evaluation in the middle ear].

New developments on biomaterials are important in surgery. The behavior of a new membrane produced from sugarcane will be evaluated in the middle ear of rats. This study analyzed the results from the interaction of the sugarcane-base biopolymer membrane in the middle ear of a rat.